Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | YAP1 | P46937 | 1/20 | 0.37 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12358259 | 0.77 | LMNA (0.49) | LMNAALDH1A1POLBKDM4ETSHR | |
| SCHEMBL4341158 | 0.77 | PRCP (0.48) | ALDH1A1KDM4EPRCP | |
| SCHEMBL8205127 | 0.76 | CHRNB2 (0.41) | LMNAALDH1A1SMN1; SMN2POLBTSHR | |
| SCHEMBL21393239 | 0.72 | POLB (0.54) | LMNAALDH1A1SMN1; SMN2POLBKDM4E | |
| SCHEMBL14266758 | 0.72 | LMNA (0.47) | LMNAALDH1A1SMN1; SMN2POLBNPC1 | |
| SCHEMBL27763359 | 0.71 | PRCP (0.46) | PRCP | |
| SCHEMBL1428541 | 0.71 | LMNA (0.46) | LMNAALDH1A1SMN1; SMN2POLBTSHR | |
| SCHEMBL11362948 | 0.71 | LMNA (0.46) | LMNAALDH1A1SMN1; SMN2POLBKDM4E | |
| SCHEMBL10762717 | 0.70 | HSD17B10 (0.42) | LMNAALDH1A1SMN1; SMN2KDM4EPRCP | |
| SCHEMBL28310981 | 0.69 | POLB (0.64) | LMNAALDH1A1SMN1; SMN2POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1250336-B1 | PIPERIDINE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2004-05-12 | — | — | EP | disclosed |