Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616621 | 0.92 | SMN1; SMN2 (0.40) | HPGDALDH1A1KDM4EHSD17B10USP2 | |
| SCHEMBL6674746 | 0.91 | MAPK14 (0.38) | HPGDALDH1A1KDM4EUSP2EPHX2 | |
| SCHEMBL6602660 | 0.91 | TERT (0.36) | HPGDALDH1A1KDM4EHSD17B10NPC1 | |
| SCHEMBL6619787 | 0.90 | MAPK14 (0.41) | ALDH1A1USP2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6614450 | 0.90 | ALDH1A1 (0.41) | HPGDALDH1A1KDM4EHSD17B10USP2 | |
| SCHEMBL6617446 | 0.89 | CYP3A4 (0.39) | HPGDALDH1A1KDM4EUSP2EPHX2 | |
| SCHEMBL6614350 | 0.89 | ALDH1A1 (0.41) | HPGDALDH1A1KDM4EHSD17B10NPC1 | |
| SCHEMBL6615761 | 0.88 | KDM5A (0.39) | HPGDALDH1A1KDM4EUSP2EPHX2 | |
| SCHEMBL6620495 | 0.87 | MAPK14 (0.39) | HPGDALDH1A1KDM4EUSP2NPC1 | |
| SCHEMBL6619748 | 0.87 | ALDH1A1 (0.38) | HPGDALDH1A1KDM4EUSP2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |