Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 12/20 | 0.43 |
| ▸ | NPC1 | O15118 | 10/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6621069 | 0.89 | CRACR2A (0.44) | CRACR2ARAB9ANPC1SMN1; SMN2EPHX2 | |
| SCHEMBL6616214 | 0.89 | NAMPT (0.46) | CRACR2ARAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL6617207 | 0.88 | CRACR2A (0.46) | CRACR2ARAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL6618968 | 0.88 | CRACR2A (0.42) | CRACR2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6615008 | 0.86 | SMN1; SMN2 (0.47) | CRACR2ARAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL6615742 | 0.86 | CRACR2A (0.44) | CRACR2ARAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL6603258 | 0.83 | ALDH1A1 (0.44) | RAB9ANPC1SMN1; SMN2MAPTGAA | |
| SCHEMBL6616766 | 0.82 | ADCY1 (0.41) | RAB9ANPC1SMN1; SMN2MAPTNPSR1 | |
| SCHEMBL6617846 | 0.82 | ROCK2 (0.40) | CRACR2ARAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL6616663 | 0.82 | RAB9A (0.39) | RAB9ANPC1SMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |