Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617672 | 0.86 | CRACR2A (0.47) | CRACR2AKDM4ELMNATDP1POLB | |
| SCHEMBL6617027 | 0.84 | CYP3A4 (0.41) | KDM4ELMNAPOLBMEN1KMT2A | |
| SCHEMBL6618182 | 0.84 | MEN1 (0.43) | CRACR2ALMNAMEN1KMT2AACKR3 | |
| SCHEMBL6617260 | 0.84 | RAB9A (0.48) | KDM4ELMNATDP1POLBMEN1 | |
| SCHEMBL6617816 | 0.84 | KMT2A (0.52) | KDM4ELMNAMEN1KMT2AGAA | |
| SCHEMBL6617757 | 0.84 | CRACR2A (0.45) | CRACR2AKDM4ELMNATDP1POLB | |
| SCHEMBL6606741 | 0.83 | JAK2 (0.43) | CRACR2ASMN1; SMN2RAB9A | |
| SCHEMBL6626821 | 0.83 | RAF1 (0.46) | LMNAPOLBACKR3 | |
| SCHEMBL6615052 | 0.83 | MEN1 (0.42) | KDM4EPOLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6621026 | 0.83 | CRACR2A (0.46) | CRACR2AKDM4ELMNATDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |