Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6619006 | 0.95 | CRACR2A (0.46) | CRACR2AKDM4EPOLBMEN1KMT2A | |
| SCHEMBL6621127 | 0.87 | MEN1 (0.41) | MEN1KMT2ALMNATP53MAPT | |
| SCHEMBL6616031 | 0.86 | RAB9A (0.40) | KDM4EMEN1KMT2ALMNAACKR3 | |
| SCHEMBL6617757 | 0.86 | CRACR2A (0.45) | CRACR2AKDM4EPOLBMEN1KMT2A | |
| SCHEMBL6619126 | 0.86 | CRACR2A (0.48) | CRACR2AKDM4EPOLBMEN1KMT2A | |
| SCHEMBL6604618 | 0.85 | RAB9A (0.40) | CRACR2AKDM4EMEN1KMT2ALMNA | |
| SCHEMBL6618565 | 0.85 | ALDH1A1 (0.43) | KDM4EPOLBLMNAALDH1A1MAPT | |
| SCHEMBL6687699 | 0.84 | KMT2A (0.48) | KDM4EPOLBMEN1KMT2ALMNA | |
| SCHEMBL6621026 | 0.84 | CRACR2A (0.46) | CRACR2AKDM4EPOLBMEN1KMT2A | |
| SCHEMBL6605166 | 0.84 | TYK2 (0.43) | CRACR2AACKR3RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |