Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617307 | 0.95 | CRACR2A (0.44) | CRACR2AKDM4EKMT2AMEN1POLB | |
| SCHEMBL6614832 | 0.91 | CRACR2A (0.47) | CRACR2AKDM4EKMT2AMEN1POLB | |
| SCHEMBL6620772 | 0.88 | MEN1 (0.40) | KMT2AMEN1NAMPTMAPT | |
| SCHEMBL6621026 | 0.87 | CRACR2A (0.46) | CRACR2AKDM4EKMT2AMEN1POLB | |
| SCHEMBL6617319 | 0.87 | RAB9A (0.40) | CRACR2AKDM4EKMT2AMEN1NAMPT | |
| SCHEMBL6617672 | 0.86 | CRACR2A (0.47) | CRACR2AKDM4EKMT2AMEN1POLB | |
| SCHEMBL6608110 | 0.86 | CRACR2A (0.44) | CRACR2AKDM4ENAMPTLMNATDP1 | |
| SCHEMBL6608859 | 0.86 | CRACR2A (0.46) | CRACR2ANAMPTLMNAGAASTAT3 | |
| SCHEMBL6610153 | 0.86 | MEN1 (0.41) | CRACR2AKMT2AMEN1NAMPTMAPT | |
| SCHEMBL6614766 | 0.85 | ALDH1A1 (0.41) | KDM4EPOLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |