Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.57 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.57 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.55 |
| ▸ | ACMSD | Q8TDX5 | 5/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.51 |
| ▸ | DHFR | P00374 | 1/20 | 0.51 |
| ▸ | HNF4A | P41235 | 1/20 | 0.51 |
| ▸ | ERN1 | O75460 | 6/20 | 0.50 |
| ▸ | UNG | P13051 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | NAT1 | P18440 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29954973 | 0.85 | ACMSD (0.68) | TRIM24TRIM33ACMSDMCL1DHFR | |
| SCHEMBL28676105 | 0.85 | ACMSD (0.68) | TRIM24TRIM33ACMSDMCL1DHFR | |
| SCHEMBL10513712 | 0.85 | PTPN1 (0.51) | GSTA1HNF4AUNGMEN1USP2 | |
| SCHEMBL10621564 | 0.85 | GSTA1 (0.74) | GSTA1ACMSDMCL1DHFRHNF4A | |
| SCHEMBL8054721 | 0.81 | GSTA1 (0.74) | GSTA1ACMSDMCL1DHFRHNF4A | |
| SCHEMBL8133312 | 0.77 | ACMSD (0.69) | TRIM24TRIM33GSTA1ACMSDMCL1 | |
| SCHEMBL28677845 | 0.77 | ERN1 (0.56) | TRIM24TRIM33ACMSDMCL1DHFR | |
| SCHEMBL5390637 | 0.76 | GSTA1 (0.61) | GSTA1ACMSDMCL1DHFRHNF4A | |
| SCHEMBL2560683 | 0.76 | ACMSD (0.67) | TRIM24TRIM33ACMSDMCL1DHFR | |
| SCHEMBL17309253 | 0.76 | TRIM24 (0.59) | TRIM24TRIM33GSTA1ACMSDMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463718-A1 | 2-SUBSTITUTED THIAZOLIDINONE AND OXAZOLIDINONE DERIVATIVES FOR THE INHIBITION OF PHOSPHATASES AND THE TREATMENT OF CANCER | Incyte San Diego Incorporated (US) | 2004-10-06 | — | — | EP | disclosed |
| US-20040097566-A1 | 2-Substituted thiazolidinone and oxazolidinone derivatives for the inhibition of phosphatases and the treatment of cancer | INCYTE SAN DIEGO INCORPORATED | 2004-05-20 | — | — | US | disclosed |
| WO-2003050098-A1 | 2-SUBSTITUTED THIAZOLIDINONE AND OXAZOLIDINONE DERIVATIVES FOR THE INHIBITION OF PHOSPHATASES AND THE TREATMENT OF CANCER | INCYTE SAN DIEGO INCORPORATED (US) | 2003-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097566-A1 | 2-Substituted thiazolidinone and oxazolidinone derivatives for the inhibition of phosphatases and the treatment of cancer | PTPA, PTPRC, PTPRCAP | TRIM24 2930/4885TRIM33 3336/4885GSTA1 1961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.