Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.60 |
| ▸ | TMPRSS4 | Q9NRS4 | 3/20 | 0.52 |
| ▸ | XDH | P47989 | 2/20 | 0.49 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.43 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19249058 | 0.83 | TRPA1 (0.57) | XDHALDH1A1LMNAJAK2JAK1 | |
| SCHEMBL19249057 | 0.82 | ALDH1A1 (0.49) | XDHALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL12670950 | 0.80 | TRPA1 (0.56) | XDHALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL1417628 | 0.80 | FLT1 (0.54) | XDHALDH1A1LMNAJAK2JAK1 | |
| SCHEMBL546514 | 0.79 | CA12 (0.61) | TMPRSS4XDHP2RX1LMNAMEN1 | |
| SCHEMBL19074375 | 0.78 | ALOX5 (0.70) | ALOX5XDHP2RX1ALDH1A1LMNA | |
| SCHEMBL23854882 | 0.77 | TMPRSS4 (0.41) | ALOX5TMPRSS4P2RX1ALDH1A1HPGD | |
| SCHEMBL21884387 | 0.77 | TMPRSS4 (0.41) | ALOX5TMPRSS4P2RX1ALDH1A1HPGD | |
| SCHEMBL311893 | 0.76 | TMPRSS4 (0.52) | TMPRSS4XDHP2RX1ALDH1A1HPGD | |
| SCHEMBL30591460 | 0.76 | ALOX5 (0.66) | ALOX5TMPRSS4XDHP2RX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047695-B1 | NOVEL BISPIDINE ANTIARRHYTHMIC COMPOUNDS | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | disclosed |
| US-6291475-B1 | 3,7-DIAZABICYCLO(3.3.1)NONANE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-09-18 | — | — | US | disclosed |