Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616778 | 0.95 | JAK2 (0.41) | JAK2JAK3ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6618768 | 0.91 | MEN1 (0.46) | JAK3ALDH1A1SMN1; SMN2ALOX12POLB | |
| SCHEMBL6631319 | 0.88 | JAK2 (0.39) | JAK2JAK3ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6614766 | 0.87 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2POLBNPC1RAB9A | |
| SCHEMBL6620487 | 0.86 | CHRNA7 (0.37) | ALDH1A1SMN1; SMN2LMNACHRNA7NPC1 | |
| SCHEMBL6618491 | 0.86 | MEN1 (0.45) | JAK3ALDH1A1SMN1; SMN2ALOX12POLB | |
| SCHEMBL6622540 | 0.86 | RAB9A (0.44) | ALDH1A1SMN1; SMN2LMNAPOLBNPC1 | |
| SCHEMBL6617042 | 0.85 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2POLBNPC1RAB9A | |
| SCHEMBL6675599 | 0.85 | NPC1 (0.45) | ALDH1A1SMN1; SMN2LMNAPOLBNPC1 | |
| SCHEMBL6616682 | 0.85 | NAMPT (0.42) | ALDH1A1SMN1; SMN2LMNARECQLPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |