Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618491 | 0.95 | MEN1 (0.45) | MEN1KMT2AHSD17B10GLAPOLB | |
| SCHEMBL6618170 | 0.91 | MEN1 (0.47) | MEN1KMT2APOLBALDH1A1NPC1 | |
| SCHEMBL6619573 | 0.91 | JAK2 (0.43) | MEN1KMT2APOLBALDH1A1NPC1 | |
| SCHEMBL6618519 | 0.91 | ALDH1A1 (0.42) | MEN1KMT2AHSD17B10POLBALDH1A1 | |
| SCHEMBL6621361 | 0.91 | JAK2 (0.43) | MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL6617523 | 0.91 | NPSR1 (0.44) | MEN1KMT2AHSD17B10GLAALDH1A1 | |
| SCHEMBL6606378 | 0.89 | CNR1 (0.40) | MEN1KMT2APOLBGAAALDH1A1 | |
| SCHEMBL6614362 | 0.88 | HRH3 (0.43) | MEN1KMT2AHSD17B10POLBGAA | |
| SCHEMBL6622866 | 0.88 | KDM4E (0.40) | MEN1KMT2APOLBALDH1A1NPC1 | |
| SCHEMBL6616981 | 0.88 | GNRHR (0.41) | MEN1KMT2AHSD17B10POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |