Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 15/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PDE1A | P54750 | 3/20 | 0.48 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.48 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PDE6C | P51160 | 3/20 | 0.47 |
| ▸ | ABCC5 | O15440 | 2/20 | 0.47 |
| ▸ | PDE2A | O00408 | 2/20 | 0.47 |
| ▸ | PDE9A | O76083 | 2/20 | 0.47 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6621801 | 0.86 | PDE5A (0.62) | PDE5AKMT2APDE3BPDE3AKDM4E | |
| SCHEMBL6622526 | 0.86 | PDE5A (0.59) | PDE5AMTORPDE3BPDE3APDE1A | |
| SCHEMBL931 | 0.81 | PDE5A (0.68) | PDE5AKMT2APDE3BPDE3AKDM4E | |
| SCHEMBL6621924 | 0.76 | PDE5A (0.57) | PDE5AKMT2AMTORPDE3BPDE3A | |
| SCHEMBL22791902 | 0.74 | PDE5A (0.70) | PDE5AKMT2AMTORPDE3BPDE3A | |
| SCHEMBL3313876 | 0.74 | KMT2A (0.70) | PDE5AKMT2APDE3BPDE3AKDM4E | |
| SCHEMBL1529 | 0.73 | PDE5A (1.00) | PDE5AKMT2AMTORPDE3BPDE3A | |
| SCHEMBL1071 | 0.73 | KMT2A (0.83) | PDE5AKMT2APDE3BPDE3AKDM4E | |
| SCHEMBL21067487 | 0.73 | PDE5A (1.00) | PDE5AKMT2AMTORPDE3BPDE3A | |
| SCHEMBL29655374 | 0.73 | KMT2A (0.83) | PDE5AKMT2APDE3BPDE3AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109814-B1 | 5-HETEROCYCLYL PYRAZOLO 4,3-D]PYRIMIDIN-7-ONES FOR THE TREATMENT OF MALE ERECTILE DYSFUNCTION | ORTHO MCNEIL PHARM INC (US) | 2004-04-21 | — | — | EP | disclosed |
| EP-1109814-A1 | 5-HETEROCYCLYL PYRAZOLO 4,3-D]PYRIMIDIN-7-ONES FOR THE TREATMENT OF MALE ERECTILE DYSFUNCTION | Ortho-McNeil Pharmaceutical, Inc. (US) | 2001-06-27 | — | — | EP | disclosed |
| US-6077841-A | FOR TREATING SEXUAL DISORDERS, MALE IMPOTENCY, HEART FAILURE, PULMONARY HYPERTENSION, AND ANGINA | JANSSEN PHARMACEUTICA, N.V. (BE) | 2000-06-20 | — | — | US | disclosed |
| WO-2000014088-A1 | 5-HETEROCYCLYL PYRAZOLO[4,3-D]PYRIMIDIN-7-ONES FOR THE TREATMENT OF MALE ERECTILE DYSFUNCTION | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-03-16 | — | — | WO | disclosed |