Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 13/20 | 0.72 |
| ▸ | CTSL | P07711 | 7/20 | 0.72 |
| ▸ | CTSS | P25774 | 8/20 | 0.50 |
| ▸ | CTSB | P07858 | 2/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.44 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4713680 | 0.84 | CTSK (1.00) | CTSKCTSLCTSSCTSB | |
| SCHEMBL6622519 | 0.83 | CTSK (0.61) | CTSKCTSLCTSSCTSBPSEN1 | |
| SCHEMBL4309572 | 0.83 | CTSK (0.67) | CTSKCTSLCTSSCTSBPSEN1 | |
| SCHEMBL4310706 | 0.83 | CTSK (0.67) | CTSKCTSLCTSSCTSBPSEN1 | |
| SCHEMBL4039064 | 0.83 | CTSK (0.67) | CTSKCTSLCTSSCTSBPSEN1 | |
| SCHEMBL6620125 | 0.82 | CTSL (0.54) | CTSKCTSLCTSSCTSBKAT6A | |
| SCHEMBL6620554 | 0.82 | CTSL (0.56) | CTSKCTSLPSEN1PSEN2APH1B | |
| SCHEMBL7391778 | 0.78 | CTSK (0.71) | CTSKCTSLCTSSCTSBPSEN1 | |
| SCHEMBL6621742 | 0.76 | CTSK (0.52) | CTSKCTSLCTSSCTSBPSEN1 | |
| SCHEMBL9261215 | 0.76 | CTSK (0.50) | CTSKCTSLCTSSCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1067894-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-09-08 | — | — | EP | disclosed |
| US-6518267-B1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2003-02-11 | — | — | US | disclosed |
| EP-1067894-A2 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999059526-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-25 | — | — | WO | disclosed |