Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.54 |
| ▸ | CTSK | P43235 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | CTSA | P10619 | 5/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4129755 | 0.84 | CTSL (0.47) | CTSLCTSKMEN1KMT2ACTSS | |
| SCHEMBL6619802 | 0.82 | CTSK (0.72) | CTSLCTSKCTSBCTSSKAT6A | |
| SCHEMBL6620554 | 0.78 | CTSL (0.56) | CTSLCTSKMEN1KMT2AKAT6A | |
| SCHEMBL4775169 | 0.78 | CTSK (0.56) | CTSLCTSKCTSBCTSS | |
| SCHEMBL7377688 | 0.75 | PTGS1 (0.61) | MEN1KMT2AFFAR1 | |
| SCHEMBL20546345 | 0.74 | KMT2A (0.52) | CTSLCTSKKMT2ACTSBCTSS | |
| SCHEMBL20546348 | 0.74 | KMT2A (0.52) | CTSLCTSKKMT2ACTSBCTSS | |
| SCHEMBL7167580 | 0.74 | PTGS2 (0.51) | CTSKCTSSFFAR1PPARGMAPT | |
| SCHEMBL6622519 | 0.72 | CTSK (0.61) | CTSLCTSKCTSBCTSSKAT6A | |
| SCHEMBL27589462 | 0.72 | KAT6A (0.48) | CTSLCTSKCTSBCTSSKAT6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1067894-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-09-08 | — | — | EP | disclosed |
| US-6518267-B1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2003-02-11 | — | — | US | disclosed |
| EP-1067894-A2 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999059526-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-25 | — | — | WO | disclosed |