Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 11/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615817 | 1.00 | PTGS2 (0.41) | PTGS2TP53MDM2PTGS1LMNA | |
| SCHEMBL59197 | 0.70 | PTGS2 (0.74) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| SCHEMBL2436189 | 0.70 | APP (0.56) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| SCHEMBL11468007 | 0.67 | APP (0.64) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| Hexaprofen SCHEMBL2111016 | 0.66 | APP (0.67) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| SCHEMBL185702 | 0.65 | PTGS2 (0.61) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| SCHEMBL1711069 | 0.65 | PTGS2 (0.61) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| SCHEMBL4767889 | 0.65 | PTGS2 (0.61) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| SCHEMBL5727201 | 0.65 | CCNA2 (0.53) | PTGS2TP53PTGS1LMNACYP2C9 | |
| SCHEMBL7542404 | 0.65 | PTGS1 (0.60) | PTGS2PTGS1LMNACYP2C9AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406899-A2 | PHENYLACETAMIDO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003008365-A2 | PHENYLACETAMIDO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA S.P.A. (IT) | 2003-01-30 | — | — | WO | disclosed |