Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ACACB | O00763 | 5/20 | 0.49 |
| ▸ | PPARD | Q03181 | 2/20 | 0.49 |
| ▸ | PPARA | Q07869 | 2/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.45 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1610078 | 0.86 | TDP1 (0.48) | TDP1S1PR3TSHRLMNAACACB | |
| SCHEMBL8297600 | 0.78 | MMP9 (0.51) | — | |
| SCHEMBL8298145 | 0.78 | MMP12 (0.62) | TDP1TSHRLMNAACACBPPARD | |
| SCHEMBL1610156 | 0.78 | MMP2 (0.51) | TSHRLMNA | |
| SCHEMBL1609669 | 0.77 | TSHR (0.43) | TDP1TSHRLMNAACACBPPARD | |
| SCHEMBL1610092 | 0.77 | TSHR (0.45) | TDP1S1PR3TSHRLMNAACACB | |
| SCHEMBL8297616 | 0.76 | MMP2 (0.43) | TSHRLMNA | |
| SCHEMBL21900753 | 0.75 | SMN1; SMN2 (0.54) | TDP1TSHRACACBS1PR1MAPK1 | |
| SCHEMBL8298149 | 0.75 | MMP12 (0.46) | TDP1S1PR3TSHRLMNAACACB | |
| SCHEMBL15875342 | 0.75 | TDP1 (0.55) | TDP1S1PR3TSHRLMNAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476438-A1 | OXA- AND THIADIAZOLES AND THEIR USE AS METALLOPROTEINASE INHIBITORS | Vernalis (Oxford) Ltd (GB) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003070711-A1 | OXA- AND THIADIAZOLES AND THEIR USE AS METALLOPROTEINASE INHIBITORS | VERNALIS (OXFORD) LTD (GB) | 2003-08-28 | — | — | WO | disclosed |