Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 9/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 6/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.40 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.40 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6620165 | 0.93 | RAF1 (0.44) | RAF1BRAFKCNK3LMNAACKR3 | |
| SCHEMBL6685899 | 0.90 | RAF1 (0.42) | RAF1BRAFKCNK3ACKR3POLB | |
| SCHEMBL6614038 | 0.88 | KCNK3 (0.44) | RAF1BRAFKCNK3LMNAACKR3 | |
| SCHEMBL6616122 | 0.87 | RAF1 (0.46) | RAF1BRAFPOLBCTDSP1 | |
| SCHEMBL6672260 | 0.87 | MEN1 (0.45) | RAF1BRAFKCNK3 | |
| SCHEMBL6617712 | 0.86 | RAF1 (0.44) | RAF1BRAFKCNK3LMNAPOLB | |
| SCHEMBL6651874 | 0.86 | POLB (0.47) | RAF1BRAFPOLBCTDSP1 | |
| SCHEMBL6618475 | 0.86 | RAB9A (0.42) | NAMPTPOLBKCNJ6KCNJ5KCNJ3 | |
| SCHEMBL6618645 | 0.86 | TP53 (0.49) | RAF1BRAFKCNK3LMNAPOLB | |
| SCHEMBL6617441 | 0.86 | RAF1 (0.45) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |