Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 12/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6622661 | 0.78 | GRIN2B (0.63) | GRIN2BSIGMAR1GRIN1POLBKMT2A | |
| SCHEMBL7682331 | 0.77 | GRIN2B (0.56) | GRIN2BSIGMAR1GRIN1POLBKMT2A | |
| SCHEMBL6620169 | 0.75 | GRIN2B (0.53) | GRIN2BSIGMAR1GRIN1POLBKMT2A | |
| SCHEMBL6620465 | 0.72 | GRIN2B (0.62) | GRIN2BSIGMAR1GRIN1POLBKMT2A | |
| SCHEMBL8096625 | 0.70 | GRIN2B (1.00) | GRIN2BSIGMAR1GRIN1 | |
| SCHEMBL6620329 | 0.68 | TNF (0.38) | — | |
| SCHEMBL6702591 | 0.68 | NOS1 (0.51) | SIGMAR1POLB | |
| SCHEMBL6620349 | 0.68 | NOS1 (0.35) | — | |
| SCHEMBL6701134 | 0.66 | DAGLA (0.39) | — | |
| SCHEMBL8092549 | 0.64 | GRIN2B (1.00) | GRIN2BSIGMAR1GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891332-B1 | 6-PHENYLPYRIDYL-2-AMINE DERIVATIVES | PFIZER (US) | 2004-03-17 | — | — | EP | disclosed |
| US-6465491-B2 | NITRIC OXIDE SYNTHASE INHIBITOR; NERVOUS SYSTEM DISORDERS | PFIZER INC. | 2002-10-15 | — | — | US | disclosed |
| US-20010034348-A1 | 6-phenylpyridyl-2-amine derivatives | LOWE JOHN A (US) | 2001-10-25 | — | — | US | disclosed |
| US-6235747-B1 | NITRIC OXIDE SYNTHASE INHIBITOR | PFIZER INC. | 2001-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010034348-A1 | 6-phenylpyridyl-2-amine derivatives | NOS2, NOS3, NOS1 | GRIN2B 72/4885SIGMAR1 696/4885GRIN1 61/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.