Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 3/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 3/20 | 0.44 |
| ▸ | CTSB | P07858 | 2/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6620619 | 1.00 | KMT2A (0.47) | KMT2AL3MBTL1CTSLPDE4BCTSK | |
| SCHEMBL3735969 | 0.91 | CASP3 (0.47) | CTSLCTSKCTSBCTSSCASP3 | |
| SCHEMBL4704687 | 0.85 | SMN1; SMN2 (0.47) | KMT2AL3MBTL1CTSLPDE4BCTSK | |
| SCHEMBL10825520 | 0.84 | CASP3 (0.54) | CTSLCTSKCTSSCASP3 | |
| SCHEMBL14917824 | 0.84 | FPR2 (0.54) | KMT2AL3MBTL1PDE4BNPC1RAB9A | |
| SCHEMBL19716730 | 0.84 | FPR2 (0.54) | KMT2AL3MBTL1PDE4BNPC1RAB9A | |
| SCHEMBL17948796 | 0.83 | CASP3 (0.50) | KMT2AL3MBTL1CTSLSCN9ACASP3 | |
| SCHEMBL21685721 | 0.83 | CTSK (0.56) | KMT2AL3MBTL1CTSLPDE4BCTSK | |
| SCHEMBL7413298 | 0.82 | ELANE (0.46) | L3MBTL1CTSLCTSKCTSBCTSS | |
| SCHEMBL6619158 | 0.82 | ELANE (0.46) | L3MBTL1CTSLCTSKCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891362-B1 | PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE | GLAXO GROUP LTD (GB) | 2004-03-17 | — | — | EP | disclosed |
| US-6215002-B1 | CYCLIZATION, DEBLOCKING, DEPROTECTION, SULFONATION, CONDENSATION, AMIDATION; ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS | GLAXO WELLCOME INC. | 2001-04-10 | — | — | US | disclosed |
| EP-0973775-A1 | PYROLOPYRROLONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-01-26 | — | — | EP | disclosed |
| US-5994344-A | BRONCHITIS THERAPY | GLAXO WELLCOME INC. (US) | 1999-11-30 | — | — | US | disclosed |
| WO-1998043975-A1 | PYROLOPYRROLONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1998-10-08 | — | — | WO | disclosed |