Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 2/20 | 0.47 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.47 |
| ▸ | ITGAL | P20701 | 2/20 | 0.47 |
| ▸ | ECE1 | P42892 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 5/20 | 0.42 |
| ▸ | CA1 | P00915 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6620753 | 1.00 | ITGB2 (0.47) | ITGB2ICAM1ITGALECE1CA2 | |
| SCHEMBL19463542 | 1.00 | ITGB2 (0.47) | ITGB2ICAM1ITGALECE1CA2 | |
| SCHEMBL16908014 | 0.86 | ECE1 (0.42) | ITGB2ICAM1ITGALECE1CA2 | |
| SCHEMBL7832189 | 0.84 | CA2 (0.47) | CA2CA1TMPRSS15FOLH1 | |
| SCHEMBL5611391 | 0.84 | CA2 (0.47) | CA2CA1TMPRSS15FOLH1 | |
| SCHEMBL473070 | 0.84 | CA2 (0.47) | CA2CA1TMPRSS15FOLH1 | |
| SCHEMBL3142495 | 0.81 | KMT2A (0.47) | CA2CA1KMT2AMRGPRX4FOLH1 | |
| SCHEMBL3142506 | 0.81 | KMT2A (0.47) | CA2CA1KMT2AMRGPRX4FOLH1 | |
| SCHEMBL11401620 | 0.81 | ITGB2 (0.33) | ITGB2ICAM1ITGALECE1CA2 | |
| SCHEMBL5777336 | 0.81 | ECE1 (0.44) | ITGB2ICAM1ITGALECE1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891362-B1 | PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE | GLAXO GROUP LTD (GB) | 2004-03-17 | — | — | EP | disclosed |
| US-6215002-B1 | CYCLIZATION, DEBLOCKING, DEPROTECTION, SULFONATION, CONDENSATION, AMIDATION; ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS | GLAXO WELLCOME INC. | 2001-04-10 | — | — | US | disclosed |
| EP-1003748-A2 | PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE | GLAXO GROUP LIMITED (GB) | 2000-05-31 | — | — | EP | disclosed |
| US-6057457-A | ENZYME INHIBITORS FOR PROTEASE OR ENZYMES OF HYDROLYSIS | GLAXO WELLCOME INC. (US) | 2000-05-02 | — | — | US | disclosed |
| US-5994344-A | BRONCHITIS THERAPY | GLAXO WELLCOME INC. (US) | 1999-11-30 | — | — | US | disclosed |
| WO-1999012933-A2 | PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE | GLAXO GROUP LIMITED (GB) | 1999-03-18 | — | — | WO | disclosed |