Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 4/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | GUSB | P08236 | 4/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27510735 | 0.98 | POLB (0.42) | POLBMAOBMAOABRD4CREBBP | |
| SCHEMBL18614556 | 0.80 | MAOA (0.37) | POLBMAOBMAOAABCB1GUSB | |
| SCHEMBL30703071 | 0.80 | POLB (0.44) | POLBMAOBMAOABRD4CREBBP | |
| SCHEMBL1328841 | 0.77 | POLB (0.43) | POLBMAOBMAOABRD4CREBBP | |
| SCHEMBL18383190 | 0.77 | POLB (0.43) | POLBMAOBMAOABRD4CREBBP | |
| SCHEMBL18383187 | 0.77 | POLB (0.43) | POLBMAOBMAOABRD4CREBBP | |
| SCHEMBL28019281 | 0.77 | MAOB (0.41) | MAOBMAOAABCB1GUSBESR1 | |
| SCHEMBL10764252 | 0.77 | MAOA (0.41) | MAOBMAOAGUSBESR1ESR2 | |
| SCHEMBL24997237 | 0.75 | MAP3K14 (0.41) | POLBAKR1B1MAP3K14 | |
| SCHEMBL24997234 | 0.75 | MAP3K14 (0.41) | POLBAKR1B1MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100338060-C | New use of substituted aminomethyl chromans | MERCK PATENT GMBH (DE) | 2007-09-19 | — | — | CN | claimed |
| US-20240018133-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2024-01-18 | — | — | US | disclosed |
| US-20210363136-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2021-11-25 | — | — | US | disclosed |
| WO-2020223536-A1 | SUBSTITUTED CYCLOLAKYLS AS MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2020-11-05 | — | — | WO | disclosed |
| US-20200347043-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2020-11-05 | — | — | US | disclosed |
| CN-1249044-C | Chromanone derivatives | MERCK PATENT GMBH (DE) | 2006-04-05 | — | — | CN | disclosed |
| EP-1434777-A1 | BENZISOTHIAZOLYL-SUBSTITUTED AMINOMETHYL CHROMANES FOR TREATING DISEASES OF THE CENTRAL NERVOUS SYSTEM | Bayer HealthCare AG (DE) | 2004-07-07 | — | — | EP | disclosed |
| CN-1451001-A | Chromanone derivatives | MERCK PATENT GMBH (DE) | 2003-10-22 | — | — | CN | disclosed |
| WO-2003029250-A1 | BENZISOTHIAZOLYL-SUBSTITUTED AMINOMETHYL CHROMANES FOR TREATING DISEASES OF THE CENTRAL NERVOUS SYSTEM | BAYER HEALTHCARE AG (DE) | 2003-04-10 | — | — | WO | disclosed |
| CN-1254335-A | Nicotinamide derivatives | PFIZER PROD INC (US) | 2000-05-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210363136-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | POLB 1759/4885MAOB 3069/4885MAOA 3585/4885 |
| US-20240018133-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | POLB 1759/4885MAOB 3069/4885MAOA 3585/4885 |
| US-20200347043-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | POLB 1759/4885MAOB 3069/4885MAOA 3585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.