Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 20/20 | 0.67 |
| ▸ | MMP2 | P08253 | 18/20 | 0.67 |
| ▸ | MMP3 | P08254 | 2/20 | 0.55 |
| ▸ | MMP8 | P22894 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10021359 | 0.90 | MMP13 (0.82) | MMP13MMP2MMP3 | |
| SCHEMBL6621824 | 0.89 | MMP13 (0.72) | MMP13MMP2MMP3MMP8 | |
| SCHEMBL6683494 | 0.89 | MMP13 (0.72) | MMP13MMP2MMP3MMP8 | |
| SCHEMBL6623823 | 0.89 | MMP13 (0.67) | MMP13MMP2MMP3MMP8 | |
| SCHEMBL6622381 | 0.88 | MMP13 (0.61) | MMP13MMP2MMP3MMP8 | |
| SCHEMBL6690639 | 0.88 | MMP13 (0.61) | MMP13MMP2MMP3MMP8 | |
| SCHEMBL6687895 | 0.86 | MMP13 (0.84) | MMP13MMP2MMP3MMP8 | |
| SCHEMBL6621337 | 0.75 | MMP13 (0.54) | MMP13MMP2MMP3 | |
| SCHEMBL6685968 | 0.74 | MMP13 (0.73) | MMP13MMP2MMP3MMP8 | |
| SCHEMBL5919194 | 0.71 | MMP2 (1.00) | MMP13MMP2MMP3MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472244-A1 | AROMATIC SULFONE HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS | Pharmacia Corporation (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003045944-A1 | AROMATIC SULFONE HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS | PHARMACIA CORPORATION (US) | 2003-06-05 | — | — | WO | disclosed |