Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 20/20 | 0.61 |
| ▸ | MMP2 | P08253 | 17/20 | 0.61 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.53 |
| ▸ | MMP3 | P08254 | 2/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6622381 | 1.00 | MMP13 (0.61) | MMP13MMP2ADAM17MMP3MMP8 | |
| SCHEMBL6621024 | 0.88 | MMP13 (0.67) | MMP13MMP2MMP3MMP8 | |
| SCHEMBL10021359 | 0.85 | MMP13 (0.82) | MMP13MMP2MMP3 | |
| SCHEMBL6623823 | 0.85 | MMP13 (0.67) | MMP13MMP2MMP3MMP8 | |
| SCHEMBL6621824 | 0.85 | MMP13 (0.72) | MMP13MMP2MMP3MMP8 | |
| SCHEMBL6683494 | 0.85 | MMP13 (0.72) | MMP13MMP2MMP3MMP8 | |
| SCHEMBL6687895 | 0.83 | MMP13 (0.84) | MMP13MMP2MMP3MMP8 | |
| SCHEMBL5919696 | 0.73 | MMP13 (0.69) | MMP13MMP2ADAM17MMP3MMP8 | |
| SCHEMBL6621337 | 0.73 | MMP13 (0.54) | MMP13MMP2MMP3 | |
| SCHEMBL10021361 | 0.72 | MMP13 (0.72) | MMP13MMP2ADAM17MMP3MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040235818-A1 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | PHARMACIA CORPORATION | 2004-11-25 | — | — | US | disclosed |
| US-20040209914-A1 | Aromatic sulfone hydroxamic acids and their use as protease inhibitors | PHARMACIA CORPORATION | 2004-10-21 | — | — | US | disclosed |
| US-6750228-B1 | UNCONTROLLED BREAKDOWN OF CONNECTIVE TISSUE BY METALLOPROTEASES IS A FEATURE OF MANY PATHOLOGICAL CONDITIONS | PHARMACIA CORPORATION | 2004-06-15 | — | — | US | disclosed |
| US-6683093-B2 | ENZYME INHIBITORS; CARDIOVASCULAR DISORDERS; ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASE | PHARMACIA CORPORATION | 2004-01-27 | — | — | US | disclosed |
| US-20030073718-A1 | Aromatic sulfone hydroxamic acids and their use as protease inhibitors | PHARMACIA CORPORATION | 2003-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235818-A1 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | MMP9, MMP13, MMP2 | MMP13 2/4885MMP2 3/4885ADAM17 28/4885 |
| US-20030073718-A1 | Aromatic sulfone hydroxamic acids and their use as protease inhibitors | MMP1, MMP7, MMP3 | MMP13 7/4885MMP2 10/4885ADAM17 27/4885 |
| US-20040209914-A1 | Aromatic sulfone hydroxamic acids and their use as protease inhibitors | MMP1, MMP7, MMP3 | MMP13 7/4885MMP2 10/4885ADAM17 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.