Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.39 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.39 |
| ▸ | FRK | P42685 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.38 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6605931 | 0.91 | ACKR3 (0.43) | TP53SMN1; SMN2NR1H4MEN1KMT2A | |
| SCHEMBL6615869 | 0.91 | NAMPT (0.41) | SMN1; SMN2NR1H4MEN1KMT2AKCNK9 | |
| SCHEMBL6617061 | 0.91 | TAOK1 (0.42) | TP53THRBMAPK14CRACR2AEPHX2 | |
| SCHEMBL6619665 | 0.90 | P2RY14 (0.41) | TP53MAPK14EPHX2MAPTPOLB | |
| SCHEMBL6615051 | 0.89 | SCN2A (0.42) | SMN1; SMN2MEN1KMT2ATRPV1MAPT | |
| SCHEMBL6616573 | 0.87 | NR1H4 (0.41) | NR1H4MAPK14MEN1KMT2ATRPV1 | |
| SCHEMBL6617539 | 0.87 | NPC1 (0.46) | TP53SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL6621456 | 0.87 | MEN1 (0.44) | SMN1; SMN2NR1H4MAPK14MEN1KMT2A | |
| SCHEMBL6623315 | 0.87 | KCNK3 (0.43) | NR1H4MAPK14EPHA3FRKMEN1 | |
| SCHEMBL6618415 | 0.86 | MEN1 (0.44) | NR1H4MEN1KMT2AKCNK9TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |