Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | FPR1 | P21462 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616726 | 0.95 | SLC1A2 (0.38) | SLC1A2KMT2AKDM4EPOLBNAMPT | |
| SCHEMBL6620279 | 0.89 | KMT2A (0.38) | SLC1A2CNR1KMT2AKDM4E | |
| SCHEMBL6651075 | 0.88 | KMT2A (0.39) | CNR1KMT2AKDM4EPOLBNAMPT | |
| SCHEMBL6620336 | 0.88 | POLB (0.40) | SLC1A2CNR1KMT2AKDM4EPOLB | |
| SCHEMBL6616479 | 0.87 | EPHX2 (0.38) | KMT2AKDM4EPOLBCRACR2AALDH1A1 | |
| SCHEMBL6617596 | 0.86 | KDM4E (0.40) | CNR1KMT2AKDM4EPOLBALDH1A1 | |
| SCHEMBL6621562 | 0.86 | CNR1 (0.39) | CNR1NAMPTMAPK1RAB9ATP53 | |
| SCHEMBL6622866 | 0.85 | KDM4E (0.40) | CNR1KMT2AKDM4EPOLBALDH1A1 | |
| SCHEMBL6615869 | 0.85 | NAMPT (0.41) | KMT2ANAMPTCRACR2A | |
| SCHEMBL6617829 | 0.85 | ALDH1A1 (0.39) | KMT2AKDM4EPOLBCRACR2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |