Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 3/20 | 0.39 |
| ▸ | HRH1 | P35367 | 3/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6622630 | 0.90 | MEN1 (0.53) | MEN1KMT2AALDH1A1KDM4EKCNH2 | |
| SCHEMBL6619543 | 0.90 | MEN1 (0.53) | MEN1KMT2AALDH1A1KDM4EKCNH2 | |
| SCHEMBL6740378 | 0.86 | HRH3 (0.42) | KCNA5HRH3ALDH1A1KDM4EKCNH2 | |
| SCHEMBL6621946 | 0.84 | MMP12 (0.50) | MEN1ALDH1A1KCNH2HRH2HRH1 | |
| SCHEMBL6322140 | 0.83 | GRIN1 (0.40) | KCNA5MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL6621505 | 0.81 | KCNA5 (0.48) | KCNA5HRH3ALDH1A1KDM4EMAPT | |
| SCHEMBL6620819 | 0.81 | GRIN2B (0.43) | MEN1KMT2AALDH1A1KDM4EKCNH2 | |
| SCHEMBL6317205 | 0.81 | GRIN2B (0.51) | MEN1KMT2AALDH1A1KDM4EGRIN1 | |
| SCHEMBL6622363 | 0.80 | MAPT (0.37) | MEN1KMT2AALDH1A1KDM4EKCNH2 | |
| SCHEMBL6742821 | 0.80 | KDM4E (0.51) | MEN1KMT2AALDH1A1KDM4EKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047695-B1 | NOVEL BISPIDINE ANTIARRHYTHMIC COMPOUNDS | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | disclosed |
| US-6291475-B1 | 3,7-DIAZABICYCLO(3.3.1)NONANE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-09-18 | — | — | US | disclosed |