Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.59 |
| ▸ | ATM | Q13315 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23461860 | 0.84 | KDM4E (0.69) | L3MBTL1ATMKDM4EAHRALDH1A1 | |
| SCHEMBL6964091 | 0.77 | KDM4E (0.71) | L3MBTL1NPC1KDM4EAHRALDH1A1 | |
| SCHEMBL29502927 | 0.77 | KDM4E (0.56) | L3MBTL1ATMNPC1KDM4EALDH1A1 | |
| SCHEMBL18702641 | 0.77 | KDM4E (0.56) | L3MBTL1ATMNPC1KDM4EALDH1A1 | |
| SCHEMBL7128108 | 0.75 | L3MBTL1 (0.57) | L3MBTL1ATMNPC1ALDH1A1MAPT | |
| SCHEMBL11309579 | 0.73 | L3MBTL1 (0.49) | L3MBTL1ATMNPC1KDM4EAHR | |
| SCHEMBL24832772 | 0.73 | ALDH1A1 (0.63) | L3MBTL1KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL20154272 | 0.72 | RAB9A (0.54) | L3MBTL1ATMNPC1ALDH1A1MAPT | |
| SCHEMBL18018241 | 0.72 | CYP2C19 (0.61) | L3MBTL1ATMKDM4EALDH1A1KMT2A | |
| SCHEMBL20154268 | 0.72 | TDP1 (0.58) | L3MBTL1ATMNPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1067894-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-09-08 | — | — | EP | disclosed |
| US-6518267-B1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2003-02-11 | — | — | US | disclosed |
| EP-1067894-A2 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999059526-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-25 | — | — | WO | disclosed |