Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | IL6 | P05231 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6621561 | 0.92 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1LMNAMAPTTP53 | |
| SCHEMBL6614537 | 0.92 | ACKR3 (0.41) | SMN1; SMN2ALDH1A1LMNAMAPTTP53 | |
| SCHEMBL6617319 | 0.91 | RAB9A (0.40) | SMN1; SMN2MAPTTP53NAMPTMEN1 | |
| SCHEMBL6618133 | 0.89 | RAB9A (0.41) | SMN1; SMN2MAPTTP53MEN1KMT2A | |
| SCHEMBL6650968 | 0.87 | RAB9A (0.42) | LMNAMAPTNAMPTMEN1KMT2A | |
| SCHEMBL6618493 | 0.86 | NPC1 (0.52) | SMN1; SMN2ALDH1A1LMNAMAPTNAMPT | |
| SCHEMBL6617061 | 0.85 | TAOK1 (0.42) | LMNAMAPTTP53NAMPTPOLB | |
| SCHEMBL6616244 | 0.85 | NAMPT (0.41) | SMN1; SMN2ALDH1A1LMNAMAPTTP53 | |
| SCHEMBL6615863 | 0.85 | RAB9A (0.40) | SMN1; SMN2LMNAMAPTTP53MEN1 | |
| SCHEMBL6618475 | 0.85 | RAB9A (0.42) | SMN1; SMN2ALDH1A1MAPTTP53NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |