Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.36 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618475 | 0.93 | RAB9A (0.42) | SMN1; SMN2ALDH1A1NAMPTMAPTTP53 | |
| SCHEMBL6619769 | 0.92 | LMNA (0.40) | SMN1; SMN2ALDH1A1LMNAMAPTACKR3 | |
| SCHEMBL6622810 | 0.92 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1LMNANAMPTMAPT | |
| SCHEMBL6614797 | 0.91 | RAB9A (0.38) | SMN1; SMN2LMNANAMPTMAPTTP53 | |
| SCHEMBL6616663 | 0.90 | RAB9A (0.39) | SMN1; SMN2LMNAMAPTTP53ACKR3 | |
| SCHEMBL6617649 | 0.89 | RAB9A (0.43) | LMNANAMPTACKR3KDM6BKDM5A | |
| SCHEMBL6620003 | 0.88 | RAB9A (0.39) | SMN1; SMN2ALDH1A1MAPTMEN1POLB | |
| SCHEMBL6616766 | 0.88 | ADCY1 (0.41) | SMN1; SMN2ALDH1A1LMNAMAPTTP53 | |
| SCHEMBL6661397 | 0.87 | CRACR2A (0.45) | SMN1; SMN2ALDH1A1MAPTACKR3MEN1 | |
| SCHEMBL6618994 | 0.87 | NPC1 (0.49) | SMN1; SMN2ALDH1A1NAMPTMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |