Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Eniporide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 2/20 | 0.62 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.62 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Eniporide SCHEMBL6619621 | 0.99 | SLC9A1 (0.63) | SLC9A1SLC9A3SLC9A2 | |
| Eniporide SCHEMBL8032919 | 0.82 | SLC9A1 (0.72) | SLC9A1SLC9A3SLC9A2 | |
| Rimeporide SCHEMBL29404681 | 0.82 | SLC9A1 (0.55) | SLC9A1 | |
| Rimeporide SCHEMBL1019630 | 0.82 | SLC9A1 (0.55) | SLC9A1 | |
| Rimeporide SCHEMBL1021018 | 0.81 | SLC9A1 (0.54) | SLC9A1 | |
| Rimeporide SCHEMBL6674301 | 0.81 | SLC9A1 (0.54) | SLC9A1 | |
| Rimeporide SCHEMBL16712397 | 0.81 | SLC9A1 (0.54) | SLC9A1 | |
| Eniporide SCHEMBL29359767 | 0.80 | SLC9A1 (0.95) | SLC9A1SLC9A3SLC9A2 | |
| Rimeporide SCHEMBL1020612 | 0.79 | SLC9A1 (0.52) | SLC9A1 | |
| SCHEMBL7352153 | 0.79 | SLC9A1 (0.62) | SLC9A1SLC9A3SLC9A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770678-B1 | Lyophilisates having improved reconstitutability | MERCK PATENT GMBH (DE) | 2004-08-03 | — | — | US | claimed |
| EP-1146863-B1 | LYOPHILISATES WITH IMPROVED RECONSTITUTIBILITY | MERCK PATENT GMBH (DE) | 2004-05-12 | — | — | EP | claimed |
| US-6770678-B1 | Lyophilisates having improved reconstitutability | MERCK PATENT GMBH (DE) | 2004-08-03 | — | — | US | disclosed |