Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | NT5E | P21589 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26622025 | 0.86 | MEN1 (0.55) | ALDH1A1HPGDMEN1KMT2ARXFP1 | |
| SCHEMBL6620676 | 0.81 | MAPT (0.51) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL10001248 | 0.78 | GPR35 (0.55) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL27716372 | 0.77 | ALDH1A1 (0.46) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL31520424 | 0.77 | POLB (0.52) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL2016154 | 0.77 | POLB (0.52) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL26622032 | 0.76 | KMT2A (0.37) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL8474949 | 0.76 | ALDH1A1 (0.45) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL50624 | 0.76 | ALDH1A1 (0.56) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL6618712 | 0.76 | KDM4E (0.49) | ALDH1A1HPGDMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474140-A1 | 2-OXAZOLAMINES AND THEIR USE AS 5-HT2B RECEPTOR ANTAGONISTS | Pharmagene Laboratories Ltd (GB) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003068226-A1 | 2-OXAZOLAMINES AND THEIR USE AS 5-HT2B RECEPTOR ANTAGONISTS | PHARMAGENE LABORATORIES LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |