Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.57 |
| ▸ | AKT1 | P31749 | 3/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | CTSB | P07858 | 2/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24736794 | 0.85 | AKT1 (0.54) | RIPK1AKT1HDAC3HDAC1HDAC2 | |
| SCHEMBL3819098 | 0.84 | AKT1 (0.52) | RIPK1AKT1HDAC3HDAC1HDAC2 | |
| SCHEMBL1520414 | 0.83 | ALOX5 (0.51) | RIPK1AKT1ALOX5CTSSL3MBTL1 | |
| SCHEMBL4213404 | 0.83 | RIPK1 (0.40) | RIPK1AKT1HDAC3HDAC1HDAC2 | |
| SCHEMBL7190668 | 0.83 | RIPK1 (0.57) | RIPK1AKT1HDAC3HDAC1HDAC2 | |
| SCHEMBL3353841 | 0.81 | AKT1 (0.54) | RIPK1AKT1HDAC3HDAC1HDAC2 | |
| SCHEMBL2061999 | 0.81 | AKT1 (0.50) | RIPK1AKT1HDAC3HDAC1HDAC2 | |
| SCHEMBL27499765 | 0.81 | ALOX5 (0.56) | ALOX5L3MBTL1MEN1KMT2A | |
| SCHEMBL20341352 | 0.80 | AKT1 (0.49) | RIPK1AKT1HDAC3HDAC1HDAC2 | |
| SCHEMBL23288368 | 0.80 | LMNA (0.60) | RIPK1AKT1HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986384-A4 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIV PITTSBURGH (US) | 2004-09-15 | — | — | EP | disclosed |
| EP-0986384-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998050029-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1998-11-12 | — | — | WO | disclosed |