Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.37 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3253302 | 0.85 | HSD11B1 (0.42) | HSD11B1SCN8ASCN1ASCN5ASCN9A | |
| SCHEMBL6612392 | 0.78 | ALDH1A1 (0.49) | ALDH1A1TSHRPOLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL6623052 | 0.78 | KMT2A (0.64) | ALDH1A1TSHRPOLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL6625477 | 0.78 | POLB (0.49) | ALDH1A1TSHRPOLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL11372035 | 0.77 | ALDH1A1 (0.59) | ALDH1A1TSHRPOLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL6626147 | 0.76 | HTT (0.59) | ALDH1A1TSHRPOLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL6628130 | 0.76 | ALDH1A1 (0.51) | ALDH1A1TSHRPOLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL6625669 | 0.75 | ALDH1A1 (0.55) | ALDH1A1TSHRPOLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL6624588 | 0.74 | KMT2A (0.64) | ALDH1A1TSHRPOLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL6624729 | 0.73 | ALDH1A1 (0.51) | ALDH1A1TSHRPOLBSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461325-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2004-09-29 | — | — | EP | claimed |
| WO-2003043999-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2003-05-30 | — | — | WO | claimed |