Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | IRS1 | P35568 | 1/20 | 0.48 |
| ▸ | GAB1 | Q13480 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615532 | 0.89 | ALDH1A1 (0.52) | KMT2AALDH1A1TSHRMEN1PKM | |
| SCHEMBL6623052 | 0.89 | KMT2A (0.64) | KMT2AALDH1A1TSHRMEN1PKM | |
| SCHEMBL6624729 | 0.88 | ALDH1A1 (0.51) | KMT2AALDH1A1TSHRMEN1PKM | |
| SCHEMBL6625259 | 0.87 | ALDH1A1 (0.53) | KMT2AALDH1A1TSHRMEN1CYP2C9 | |
| SCHEMBL6625890 | 0.86 | KMT2A (0.66) | KMT2AALDH1A1TSHRMEN1PKM | |
| SCHEMBL6625513 | 0.84 | POLB (0.51) | KMT2AALDH1A1TSHRMEN1PKM | |
| SCHEMBL3255724 | 0.83 | LMNA (0.49) | KMT2AALDH1A1MEN1SMN1; SMN2POLB | |
| SCHEMBL6625022 | 0.83 | ALDH1A1 (0.55) | KMT2AALDH1A1TSHRMEN1CYP2C9 | |
| SCHEMBL6626147 | 0.83 | HTT (0.59) | KMT2AALDH1A1TSHRMEN1CYP2C9 | |
| SCHEMBL6628130 | 0.82 | ALDH1A1 (0.51) | KMT2AALDH1A1TSHRMEN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461325-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003043999-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2003-05-30 | — | — | WO | disclosed |