Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 1/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.34 |
| ▸ | RXRB | P28702 | 4/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4967943 | 0.89 | GRN (0.42) | GRNSORT1KMT2AALDH1A1GRIN2B | |
| SCHEMBL18884697 | 0.80 | SMN1; SMN2 (0.46) | GRNSORT1GRIN2BRXRBDRD3 | |
| SCHEMBL7289415 | 0.77 | ALDH1A1 (0.33) | GRNSORT1KMT2AALDH1A1 | |
| SCHEMBL7289423 | 0.77 | ALDH1A1 (0.33) | GRNSORT1KMT2AALDH1A1 | |
| SCHEMBL9801239 | 0.75 | PDK1 (0.43) | KMT2AALDH1A1PDK1KDM4E | |
| SCHEMBL12269229 | 0.74 | PDK1 (0.47) | GRNSORT1ALDH1A1GRIN2BRXRB | |
| SCHEMBL30856536 | 0.74 | TDP1 (0.41) | GRNSORT1KMT2AGRIN2BDRD3 | |
| SCHEMBL18884696 | 0.73 | HRH3 (0.42) | GRNSORT1DRD3CCR2KCNH2 | |
| SCHEMBL19484295 | 0.73 | HRH3 (0.42) | GRNSORT1DRD3CCR2KCNH2 | |
| SCHEMBL12110191 | 0.73 | HRH3 (0.42) | GRNSORT1DRD3CCR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395553-A1 | PYRROLIDINE DERIVATIVES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002100830-A1 | PYRROLIDINE DERIVATIVES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-12-19 | — | — | WO | disclosed |