Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 2/20 | 0.49 |
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6297046 | 0.83 | ESR1 (0.62) | ESR1ALDH1A1HSD17B10HPGDTP53 | |
| SCHEMBL16794196 | 0.83 | PTGER1 (0.54) | ALDH1A1HPGDKMT2APTGER1GAA | |
| SCHEMBL5604160 | 0.82 | ESR1 (0.73) | ESR1ALDH1A1HSD17B10KMT2AMAPK1 | |
| SCHEMBL16793904 | 0.80 | PTGER1 (0.56) | ALDH1A1HSD17B10KMT2AMAPK1TSHR | |
| SCHEMBL7369338 | 0.80 | ALDH1A1 (0.54) | ESR1ALDH1A1HSD17B10HPGDTP53 | |
| SCHEMBL19065098 | 0.78 | HDAC8 (0.64) | HPGDKMT2ATSHRGAANPSR1 | |
| SCHEMBL28133849 | 0.75 | CNR1 (0.69) | ESR1ALDH1A1HSD17B10KMT2AMAPK1 | |
| SCHEMBL12481734 | 0.74 | ESR1 (0.60) | ESR1HSD17B10KMT2AMAPK1TSHR | |
| SCHEMBL27346380 | 0.74 | CNR1 (0.56) | ESR1ALDH1A1HSD17B10HPGDTP53 | |
| SCHEMBL7122553 | 0.74 | RORC (0.43) | ESR1ALDH1A1HSD17B10KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421079-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003010163-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2003-02-06 | — | — | WO | disclosed |