Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.66 |
| ▸ | MEN1 | O00255 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMO | O15229 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | IRS1 | P35568 | 1/20 | 0.46 |
| ▸ | GAB1 | Q13480 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6624588 | 0.86 | KMT2A (0.64) | KMT2AMEN1ALDH1A1TSHRPKM | |
| SCHEMBL6623052 | 0.86 | KMT2A (0.64) | KMT2AMEN1ALDH1A1TSHRPKM | |
| SCHEMBL3254971 | 0.85 | MEN1 (0.48) | KMT2AMEN1ALDH1A1PTPN1HPGD | |
| SCHEMBL6615532 | 0.84 | ALDH1A1 (0.52) | KMT2AMEN1ALDH1A1TSHRPKM | |
| SCHEMBL6625513 | 0.82 | POLB (0.51) | KMT2AMEN1ALDH1A1TSHRPKM | |
| SCHEMBL6624729 | 0.81 | ALDH1A1 (0.51) | KMT2AMEN1ALDH1A1TSHRPKM | |
| SCHEMBL6625259 | 0.78 | ALDH1A1 (0.53) | KMT2AMEN1ALDH1A1TSHRCYP2C9 | |
| SCHEMBL11372035 | 0.78 | ALDH1A1 (0.59) | KMT2AMEN1ALDH1A1TSHRHPGD | |
| SCHEMBL2179405 | 0.77 | KMO (0.58) | KMT2AMEN1ALDH1A1PTPN1HPGD | |
| SCHEMBL6625022 | 0.77 | ALDH1A1 (0.55) | KMT2AMEN1ALDH1A1TSHRCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461325-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2004-09-29 | — | — | EP | claimed |
| WO-2003043999-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2003-05-30 | — | — | WO | claimed |
| EP-1461325-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003043999-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2003-05-30 | — | — | WO | disclosed |