⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8078394 | 0.98 | — | — | |
| SCHEMBL18702384 | 0.84 | — | — | |
| SCHEMBL28226619 | 0.76 | — | — | |
| SCHEMBL7315386 | 0.76 | — | — | |
| SCHEMBL311035 | 0.76 | — | — | |
| SCHEMBL28549711 | 0.73 | — | — | |
| SCHEMBL19615410 | 0.72 | — | — | |
| SCHEMBL11128788 | 0.71 | MAPK1 (0.31) | — | |
| SCHEMBL2337798 | 0.70 | ALDH1A1 (0.41) | — | |
| SCHEMBL703230 | 0.70 | ALDH1A1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150073156-A1 | Production Method of a-Methylene Lactone | CHEIL INDUSTRIES INC. (KR) | 2015-03-12 | — | — | US | disclosed |
| EP-1165538-B1 | PROCESS FOR THE PREPARATION OF ALPHA-METHYLENELACTONES AND ALPHA-SUBSTITUTED HYDROCARBYLIDENE LACTONES | DU PONT (US) | 2004-11-17 | — | — | EP | disclosed |
| EP-0392803-B1 | Novel compounds | BEECHAM GROUP PLC (GB) | 2004-06-16 | — | — | EP | disclosed |
| US-6531616-B2 | Contacting lactone compound with an oxalate in presence of a base and a solvent to form an intermediate mixture; reacting with a formaldehyde derivative to form a product mixture; isolating alpha - substituted hydrocarbylidene lactones | E. I. DU PONT DE NEMOURS AND COMPANY | 2003-03-11 | — | — | US | disclosed |
| US-20020143195-A1 | Process for the preparation of a-methylenelactones and a-substituted hydrocarbylidene lactones | E. I. DU PONT DE NEMOURS AND COMPANY | 2002-10-03 | — | — | US | disclosed |
| US-6362346-B1 | HEATING MIXTURE OF FUROIC ACID WITH ACID CATALYST | E. I. DU PONT DE NEMOURS AND COMPANY | 2002-03-26 | — | — | US | disclosed |
| EP-1165538-A2 | PROCESS FOR THE PREPARATION OF ALPHA-METHYLENELACTONES AND ALPHA-SUBSTITUTED HYDROCARBYLIDENE LACTONES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2002-01-02 | — | — | EP | disclosed |
| US-6232474-B1 | HEATING | E. I. DU PONT DE NEMOURS AND COMPANY | 2001-05-15 | — | — | US | disclosed |
| WO-2000058298-A2 | PROCESS FOR THE PREPARATION OF α-METHYLENELACTONES AND α-SUBSTITUTED HYDROCARBYLIDENE LACTONES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2000-10-05 | — | — | WO | disclosed |
| EP-0366304-B1 | Heterocyclic derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1998-04-15 | — | — | EP | disclosed |
| US-RE35593-E | THERAPY FOR DERMENTIA | BEECHAM GROUP P.L.C. | 1997-08-19 | — | — | US | disclosed |
| US-5278170-A | Azabicylo oxime compounds | BEECHAM GROUP P.L.C. (GB) | 1994-01-11 | — | — | US | disclosed |
| US-5217975-A | AZABICYCLIC COMPOUNDS FOR TREATING DEMENTIA | BEECHAM GROUP P.L.C. (GB) | 1993-06-08 | — | — | US | disclosed |
| US-5166357-A | Nitrogen heterocylic compounds used in treatment of dementia in mammals | BEECHAM GROUP P.L.C. (GB) | 1992-11-24 | — | — | US | disclosed |
| US-5091397-A | Cognition activators | BEECHAM GROUP P.L.C. (GB) | 1992-02-25 | — | — | US | disclosed |
| EP-0402056-A2 | Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them | Beecham Group p.l.c. (GB) | 1990-12-12 | — | — | EP | disclosed |
| EP-0392803-A1 | Novel compounds | Beecham Group p.l.c. (GB) | 1990-10-17 | — | — | EP | disclosed |
| EP-0366304-A2 | Heterocyclic derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1990-05-02 | — | — | EP | disclosed |
| EP-0363085-A2 | Novel compounds | BEECHAM GROUP PLC (GB) | 1990-04-11 | — | — | EP | disclosed |