Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | STAT6 | P42226 | 1/20 | 0.35 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7196401 | 0.75 | TDP1 (0.58) | TDP1HTTKMT2AMEN1HPGD | |
| SCHEMBL3389268 | 0.67 | TDP1 (0.48) | TDP1HTTKMT2AMEN1HPGD | |
| SCHEMBL7043858 | 0.66 | TDP1 (0.43) | TDP1HTTKMT2AMEN1HPGD | |
| SCHEMBL7027115 | 0.66 | TDP1 (0.43) | TDP1HTTKMT2AMEN1HPGD | |
| SCHEMBL4553023 | 0.65 | TDP1 (0.46) | TDP1HTTKMT2AMEN1HPGD | |
| SCHEMBL7018098 | 0.64 | TDP1 (0.42) | TDP1HTTSMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL460599 | 0.64 | TDP1 (0.54) | TDP1HTTKMT2AMEN1HPGD | |
| SCHEMBL9449531 | 0.63 | TDP1 (0.44) | TDP1HTTKMT2AMEN1HPGD | |
| SCHEMBL739312 | 0.63 | GAA (0.47) | TDP1HTTKMT2AMEN1HPGD | |
| SCHEMBL29991297 | 0.63 | GAA (0.47) | TDP1HTTKMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0960108-B1 | MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2004-10-27 | — | — | EP | claimed |
| EP-0960108-B1 | MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2004-10-27 | — | — | EP | disclosed |