Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.57 |
| ▸ | MMP13 | P45452 | 17/20 | 0.57 |
| ▸ | MMP9 | P14780 | 15/20 | 0.57 |
| ▸ | MMP1 | P03956 | 14/20 | 0.57 |
| ▸ | MMP2 | P08253 | 2/20 | 0.56 |
| ▸ | MMP14 | P50281 | 1/20 | 0.56 |
| ▸ | MMP7 | P09237 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3938349 | 0.99 | ADAM17 (0.56) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6506707 | 0.88 | ADAM17 (0.52) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6628725 | 0.85 | ADAM17 (0.60) | ADAM17MMP13MMP9MMP1MMP14 | |
| Hydrochloric Acid SCHEMBL3946387 | 0.84 | ADAM17 (0.59) | ADAM17MMP13MMP9MMP1MMP14 | |
| SCHEMBL2515821 | 0.83 | MMP2 (0.43) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6498849 | 0.81 | ADAM17 (0.49) | ADAM17MMP13MMP9MMP1MMP14 | |
| SCHEMBL3946147 | 0.78 | ADAM17 (0.69) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6625851 | 0.73 | MMP13 (1.00) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL3941442 | 0.73 | ADAM17 (1.00) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6786649 | 0.72 | ADAM17 (1.00) | ADAM17MMP13MMP9MMP1MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144368-B1 | ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | WYETH CORP (US) | 2004-07-14 | — | — | EP | claimed |