Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5105404 | 0.93 | ALOX5AP (0.42) | ALOX5APFEN1GAABTKSMN1; SMN2 | |
| SCHEMBL14131623 | 0.93 | ALOX5AP (0.42) | ALOX5APFEN1GAABTKSMN1; SMN2 | |
| SCHEMBL6835425 | 0.81 | ALOX5AP (0.36) | ALOX5APFEN1GAABTKSMN1; SMN2 | |
| SCHEMBL5096561 | 0.80 | CTSK (0.44) | CTSLCTSSCTSK | |
| SCHEMBL5096565 | 0.80 | CTSK (0.44) | CTSLCTSSCTSK | |
| SCHEMBL6740606 | 0.80 | CTSK (0.52) | KMT2ACTSLCTSSCTSK | |
| SCHEMBL6740612 | 0.80 | CTSK (0.52) | KMT2ACTSLCTSSCTSK | |
| SCHEMBL5093198 | 0.80 | MMP2 (0.43) | CTSLCTSSCTSK | |
| SCHEMBL6806160 | 0.80 | CTSL (0.49) | CTSLCTSSCTSK | |
| SCHEMBL6806158 | 0.80 | CTSL (0.49) | CTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392657-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-03-10 | — | — | EP | disclosed |
| EP-1392657-A2 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2003053331-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-07-03 | — | — | WO | disclosed |