Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8487419 | 0.81 | PIM3 (0.44) | MEN1KMT2AATMKDM4EALDH1A1 | |
| SCHEMBL8487413 | 0.79 | JAK2 (0.52) | MEN1KMT2AATMKDM4EALDH1A1 | |
| SCHEMBL6622666 | 0.78 | LMNA (0.50) | MEN1KMT2AATMKDM4EALDH1A1 | |
| SCHEMBL17950801 | 0.78 | KDM4E (0.58) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL9485757 | 0.75 | MPL (0.61) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL1280991 | 0.74 | POLB (0.64) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL20919657 | 0.74 | SMN1; SMN2 (0.54) | KMT2AKDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL29043472 | 0.73 | PBRM1 (0.62) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL1194334 | 0.72 | ALDH1A1 (0.58) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL30007166 | 0.72 | PLA2G2A (0.46) | MEN1KMT2AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831094-B1 | FUSED POLYCYCLIC HETEROCYCLE DERIVATIVES | EISAI CO LTD (JP) | 2004-12-08 | — | — | EP | disclosed |
| US-5952335-A | ANTITUMOR AGENTS | EISAI CO., LTD. (JP) | 1999-09-14 | — | — | US | disclosed |
| CN-1185781-A | Fused Polycyclic Heterocyclic Derivatives | EISAI CO LTD (JP) | 1998-06-24 | — | — | CN | disclosed |
| EP-0831094-A1 | FUSED POLYCYCLIC HETEROCYCLE DERIVATIVES | Eisai Co., Ltd. (JP) | 1998-03-25 | — | — | EP | disclosed |