Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 3/20 | 0.56 |
| ▸ | CETP | P11597 | 2/20 | 0.54 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.49 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12083396 | 0.84 | EP300 (0.57) | SOAT1CETPP2RX7KMT2ASOAT2 | |
| SCHEMBL9770492 | 0.83 | HDAC3 (0.59) | CETPP2RX7MAPK1LMNATSHR | |
| SCHEMBL10630267 | 0.83 | SOAT2 (0.68) | SOAT1SOAT2HDAC3HDAC4HDAC1 | |
| SCHEMBL7521462 | 0.83 | PLK1 (0.44) | KMT2A | |
| SCHEMBL13678963 | 0.81 | SOAT2 (0.71) | SOAT1SOAT2HDAC3HDAC4HDAC1 | |
| SCHEMBL18073904 | 0.81 | EP300 (0.48) | SOAT1CETPP2RX7KMT2AHDAC3 | |
| SCHEMBL14282881 | 0.81 | CETP (0.53) | SOAT1CETPP2RX7MAPK1KMT2A | |
| SCHEMBL14282873 | 0.81 | CETP (0.53) | SOAT1CETPP2RX7LMNAKMT2A | |
| SCHEMBL5560164 | 0.81 | CNR2 (0.47) | SOAT1CETPP2RX7MAPK1LMNA | |
| SCHEMBL9395051 | 0.80 | CETP (0.77) | SOAT1CETPP2RX7MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |