Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 7/20 | 0.44 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869994 | 0.84 | KCNQ4 (0.40) | PLK1PLK3FAAHHSD17B10GPR119 | |
| SCHEMBL6626010 | 0.83 | SOAT1 (0.56) | KMT2A | |
| SCHEMBL5870594 | 0.80 | RAB9A (0.52) | PLK1PLK3ALDH1A1MEN1MAPT | |
| SCHEMBL20556160 | 0.77 | PLK1 (0.53) | PLK1PLK3KAT8PPARAALDH1A1 | |
| SCHEMBL9845820 | 0.75 | PLK1 (0.50) | PLK1PLK3KAT8PPARAALDH1A1 | |
| SCHEMBL3855724 | 0.73 | ALDH1A1 (0.66) | ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL6623104 | 0.72 | NPC1 (0.54) | PLK1PLK3ALDH1A1MAPTKMT2A | |
| SCHEMBL20504184 | 0.70 | TDP1 (0.51) | ALDH1A1HSD17B10MEN1MAPTKMT2A | |
| SCHEMBL23281438 | 0.70 | GAA (0.60) | TRPV1MEN1MAPTKMT2A | |
| SCHEMBL14984048 | 0.70 | GAA (0.72) | ALDH1A1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224175-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029012-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |