Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 12/20 | 0.50 |
| ▸ | TACR3 | P29371 | 8/20 | 0.46 |
| ▸ | TACR2 | P21452 | 8/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6957829 | 0.91 | TACR3 (0.54) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| Hydrochloric Acid SCHEMBL6958335 | 0.90 | TACR3 (0.53) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL6627408 | 0.84 | TACR3 (0.43) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL6957439 | 0.83 | TACR3 (0.46) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL6959275 | 0.83 | TACR3 (0.55) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL5431805 | 0.79 | TRPV4 (0.48) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL5447103 | 0.78 | TRPV4 (0.75) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL6953405 | 0.78 | TACR3 (0.41) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| Bromide SCHEMBL6948962 | 0.77 | TACR3 (0.39) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL6586109 | 0.75 | TRPV4 (0.43) | TRPV4TACR3TACR2OPRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377567-A1 | QUINOLINE-4-CARBOXAMIDE DERIVATIVES AS NK-3 AND NK-2 RECEPTOR ANTAGONISTS | GlaxoSmithKline S.p.A. (IT) | 2004-01-07 | — | — | EP | claimed |
| WO-2002083663-A1 | QUINOLINE-4-CARBOXAMIDE DERIVATIVES AS NK-3 AND NK-2 RECEPTOR ANTAGONISTS | GLAXOSMITHKLINE S.P.A. (IT) | 2002-10-24 | — | — | WO | claimed |