Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 8/20 | 0.41 |
| ▸ | TACR2 | P21452 | 7/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6957439 | 0.86 | TACR3 (0.46) | TACR3TACR2OPRM1KCNH2TRPV4 | |
| SCHEMBL6957829 | 0.85 | TACR3 (0.54) | TACR3TACR2OPRM1KCNH2TRPV4 | |
| Hydrochloric Acid SCHEMBL6958335 | 0.84 | TACR3 (0.53) | TACR3TACR2OPRM1KCNH2TRPV4 | |
| Hydrochloric Acid SCHEMBL6953706 | 0.81 | TACR3 (0.41) | TACR3TACR2OPRM1KCNH2TRPV4 | |
| SCHEMBL5945414 | 0.80 | TRPV4 (0.55) | TACR3TACR2OPRM1TRPV4NR1I2 | |
| SCHEMBL6959275 | 0.79 | TACR3 (0.55) | TACR3TACR2OPRM1KCNH2TRPV4 | |
| SCHEMBL6950894 | 0.79 | TACR3 (0.40) | TACR3TACR2OPRM1KCNH2TRPV4 | |
| SCHEMBL6626342 | 0.78 | TRPV4 (0.50) | TACR3TACR2OPRM1KCNH2TRPV4 | |
| Bromide SCHEMBL6948962 | 0.76 | TACR3 (0.39) | TACR3TACR2OPRM1KCNH2TRPV4 | |
| SCHEMBL6627408 | 0.75 | TACR3 (0.43) | TACR3TACR2OPRM1KCNH2TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339691-A1 | NOVEL COMPOUNDS | GlaxoSmithKline S.p.A. (IT) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002044154-A1 | NOVEL COMPOUNDS | GLAXOSMITHKLINE SPA (IT) | 2002-06-06 | — | — | WO | disclosed |