Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.35 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | RARA | P10276 | 1/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | RARG | P13631 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6257608 | 0.75 | MMP13 (0.40) | MMP13HIF1AEPAS1GAAFFAR1 | |
| SCHEMBL6231446 | 0.66 | GAA (0.56) | MMP13GAA | |
| SCHEMBL8996251 | 0.66 | TBXAS1 (0.58) | GAATBXAS1 | |
| SCHEMBL6302654 | 0.66 | MMP13 (0.82) | MMP13SLC22A8 | |
| SCHEMBL6252956 | 0.64 | MMP13 (0.49) | MMP13HIF1AEPAS1GAASLC22A8 | |
| SCHEMBL6254871 | 0.64 | MMP13 (0.40) | MMP13SLC22A8 | |
| SCHEMBL5353235 | 0.64 | TBXAS1 (0.62) | GAATBXAS1 | |
| SCHEMBL11067952 | 0.61 | TBXAS1 (0.67) | GAATBXAS1 | |
| SCHEMBL6477654 | 0.61 | MMP13 (0.52) | MMP13SLC22A8 | |
| SCHEMBL6450511 | 0.60 | MMP13 (0.48) | MMP13FFAR1SLC22A8FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434585-A1 | ALKYNE MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2004-07-07 | — | — | EP | claimed |
| WO-2003032999-A1 | ALKYNE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2003-04-24 | — | — | WO | claimed |