Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | GRK2 | P25098 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 8/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8596166 | 0.80 | PDE10A (0.41) | ALDH1A1HTTHSD17B10PDE10ATDP1 | |
| SCHEMBL9873229 | 0.77 | NPC1 (0.41) | ALDH1A1HTTHSD17B10PDE10A | |
| SCHEMBL8598436 | 0.76 | TNF (0.41) | ALDH1A1HTTHSD17B10PDE10ATDP1 | |
| Hydrochloric Acid SCHEMBL9874495 | 0.74 | ALDH1A1 (0.47) | ALDH1A1HTTHSD17B10 | |
| SCHEMBL9875402 | 0.74 | TNF (0.40) | ALDH1A1HTTHSD17B10PDE10APDE4B | |
| SCHEMBL29702360 | 0.71 | LRRK2 (0.50) | ALDH1A1HTTHSD17B10PDE10ATDP1 | |
| SCHEMBL26100427 | 0.71 | LRRK2 (0.50) | ALDH1A1HTTHSD17B10PDE10ATDP1 | |
| Ethoxycarbonyl Group SCHEMBL28815733 | 0.71 | PDE10A (0.43) | ALDH1A1HTTHSD17B10PDE10APDE4B | |
| SCHEMBL22226011 | 0.71 | NPBWR1 (0.62) | AURKAGRK2ROCK1RPS6KA1TDP1 | |
| SCHEMBL28899162 | 0.71 | NPBWR1 (0.56) | ALDH1A1HTTHSD17B10AURKAGRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124829-B1 | TRICYCLIC PHTHALAZINE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON SPA (IT) | 2004-08-04 | — | — | EP | disclosed |
| US-6525055-B1 | Allergic and inflammatory pathologies such as, for example, emphysema, chronic bronchitis, asthma and allergic rhinitis. | ZAMBON GROUP S.P.A. (IT) | 2003-02-25 | — | — | US | disclosed |