Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLM | Q9NP87 | 2/20 | 0.40 |
| ▸ | POLK | Q9UBT6 | 2/20 | 0.40 |
| ▸ | POLL | Q9UGP5 | 2/20 | 0.40 |
| ▸ | POLH | Q9Y253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 6/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4593117 | 0.79 | PRKCA (0.45) | POLMPOLKPOLLPOLHKDM4E | |
| SCHEMBL23045114 | 0.75 | KDM4E (0.48) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL29532107 | 0.74 | TRPM2 (0.41) | DDB1CRBN | |
| SCHEMBL19709723 | 0.74 | CRBN (0.67) | DDB1CRBN | |
| SCHEMBL19709560 | 0.74 | CRBN (0.67) | DDB1CRBN | |
| SCHEMBL10776993 | 0.74 | CDK2 (0.43) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL7648225 | 0.74 | CYP2A6 (0.43) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL9735524 | 0.73 | KDM4E (0.41) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL9596671 | 0.73 | KCNA3 (0.42) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL4663980 | 0.73 | EPHX2 (0.40) | KDM4EALDH1A1GAAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889042-B1 | RADICICOL DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2004-05-06 | — | — | EP | disclosed |
| US-20040053990-A1 | Radicicol derivatives | KYOWA HAKKO KOGYO CO., LTD (JP) | 2004-03-18 | — | — | US | disclosed |
| US-6635662-B2 | A 2-oxime derivative; antitumor and -carcinogenic agents; immunosuppressents; osteoporosis; enzyme inhibitors of tyrosine kinase activity | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2003-10-21 | — | — | US | disclosed |
| US-6316491-B1 | INHIBITORS OF TYROSINE KINASE USED AS ANTITUMOR OR IMMUNOSUPPRESSION AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-20010027208-A1 | Radicicol derivatives | INO YOJI (JP) | 2001-10-04 | — | — | US | disclosed |
| US-6239168-B1 | ANTITUMOR AGENTS, IMMUNOSUPPRESSANTS; TYROSINE KINASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-05-29 | — | — | US | disclosed |
| EP-0889042-A1 | RADICICOL DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1999-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053990-A1 | Radicicol derivatives | ROS1, LYN, SRC | POLM 2456/4885POLK 2809/4885POLL 2408/4885 |
| US-20010027208-A1 | Radicicol derivatives | ROS1, LYN, SRC | POLM 2511/4885POLK 2873/4885POLL 2440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.