Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | SMARCA2 | P51531 | 4/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 4/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 4/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14890430 | 0.77 | ASIC3 (0.49) | SMPD3KDM4EMAPTL3MBTL1PDPK1 | |
| SCHEMBL25481443 | 0.75 | HRH3 (0.50) | SMPD3KDM4EMAPTL3MBTL1PDPK1 | |
| SCHEMBL25481828 | 0.75 | HRH3 (0.50) | SMPD3KDM4EMAPTL3MBTL1PDPK1 | |
| SCHEMBL25481832 | 0.75 | HRH3 (0.50) | SMPD3KDM4EMAPTL3MBTL1PDPK1 | |
| SCHEMBL27099909 | 0.74 | GFER (0.47) | SMPD3KDM4EMAPTL3MBTL1PDPK1 | |
| SCHEMBL27093613 | 0.74 | GFER (0.47) | SMPD3KDM4EMAPTL3MBTL1PDPK1 | |
| SCHEMBL6628400 | 0.73 | MAPT (0.45) | SMPD3KDM4EMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL27947668 | 0.73 | BCHE (0.56) | KDM4EMAPTL3MBTL1ALDH1A1CHRM4 | |
| SCHEMBL14120128 | 0.72 | SMPD3 (0.53) | SMPD3KDM4EMAPTL3MBTL1BCHE | |
| SCHEMBL14890848 | 0.72 | SMPD3 (0.53) | SMPD3KDM4EMAPTL3MBTL1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483263-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003070727-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2003-08-28 | — | — | WO | disclosed |
| EP-1309589-A2 | UREA COMPOUNDS AND METHODS OF USES | Amgen Inc. (US) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014311-A2 | UREA COMPOUNDS AND METHODS OF USES | AMGEN INC. (US) | 2002-02-21 | — | — | WO | disclosed |