Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 6/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | CTSV | O60911 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6633675 | 0.81 | MAPT (0.46) | HTR2CTDP1HTR2BALDH1A1MAPT | |
| SCHEMBL6629684 | 0.80 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL6412122 | 0.77 | HTR2C (0.56) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL6414662 | 0.76 | HTR2C (0.72) | HTR2CHTR2BHSD17B10HTR2AFFAR1 | |
| SCHEMBL6628069 | 0.73 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL5227131 | 0.73 | MET (0.51) | — | |
| SCHEMBL30002764 | 0.71 | FFAR1 (0.66) | TDP1ALDH1A1HSD17B10MAPTLMNA | |
| SCHEMBL4228617 | 0.71 | FFAR1 (0.66) | TDP1ALDH1A1HSD17B10MAPTLMNA | |
| SCHEMBL6417254 | 0.68 | HTR2C (0.71) | HTR2CHTR2BHTR2A | |
| SCHEMBL3896352 | 0.68 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465630-A1 | CYCLIC UREA DERIVATIVES WITH 5-HT2C RECEPTOR ACTIVITY | GLAXO GROUP LIMITED (GB) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003057220-A1 | CYCLIC UREA DERIVATIVES WITH 5-HT2C RECEPTOR ACTIVITY | GLAXO GROUP LIMITED (GB) | 2003-07-17 | — | — | WO | disclosed |